Journal of the European Society for Gynaecological Endoscopy


Prenatal diagnosis of a terminal chromosome 1 (q42-q44) deletion: original case report and review of the literature

C. van Linthout1, V. Emonard1, J.S. Gatot2, X. Capelle1, F. Kridelka1, P. Emonts1, M.-C. Segghaye3

1Department of Obstetrics and Gynaecology, University of Liège, 4000 Liège, Belgium.

2Department of Clinical and Human Genetics, University of Liège, 4000 Liège, Belgium.

3Department of Paediatrics, University of Liège, 4000 Liège, Belgium.

Correspondence at: Dr. Christine Van Linthout, University of Liège, 4000 Liège, Belgium. E-mail: or


Chromosome 1 deletion, facial dysmorphy, microcephaly, non compaction of myocardium, growth retardation

Published online: Jun 30 2016


Terminal chromosome 1q deletion is rarely reported but causes typical malformations that have been well described in childhood. Clinical features include facial dysmorphy, growth and/or psychomotor retardation, brain agenesis or hypoplasia of the corpus callosum, epilepsy and occasional urogenital or cardiac malformations.

The diagnosis of this condition is usually made at birth. The rare cases of antenatal diagnosis were based on microcephaly and growth retardation. In the present case, the foetus presented with an hypoplasia of the corpus callosum, a dysmorphic profile and a single umbilical artery. The foetal echocardiography suggested a non- compaction of the left ventricular myocardium. No microcephaly or growth retardation were noted.

We compare our antenatal findings to those described in the literature with the aim to better define the antenatal phenotype of the terminal chromosome 1 deletion syndrome.