Journal of the European Society for Gynaecological Endoscopy


Surgical and functional impact of nerve-sparing radical hysterectomy for parametrial deep endometriosis: a single centre experience

A. Rosati 1, M. Pavone 1, F. Campolo 1, A. De Cicco Nardone 1, D. Raimondo 2, R. Seracchioli 2,3, G. Scambia 1, M.M. Ianieri 1

1 Division of Gynecological Oncology, Department of Women’s and Children’s Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
2 Division of Gynaecology and Human Reproduction Physiopathology, IRCCS University Hospital of Bologna, Bologna, Italy
3 Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy


radical hysterectomy, deep infiltrative endometriosis, parametrectomy, nerve-sparing, functional outcome

Published online: Jul 01 2022


Background: Deep endometriosis (DE) usually creates a distortion of the retroperitoneal anatomy and may infiltrate the parametria with an oncomimetic pathway similar to cervical cancer. The condition represents a severe manifestation of endometriosis that may result in a functional impairment of the inferior hypogastric plexus.
An extensive surgical resection may be required with an associated risk of increased neurogenic postoperative pelvic organ dysfunction.

Objectives: To evaluate the post-operative function and complications following hysterectomy with posterolateral parametrial resection for DE.

Materials and Methods: In total, 23 patients underwent radical hysterectomy for DE with the parametria involved. The severity of pain was assessed by the Visual Analogue Scale (VAS) score. The KESS, GQLI, BFLUTS and FSFI were used to examine the gastrointestinal, urinary and sexual functions respectively. Intra and post-operative complications were recorded.

Main outcome measures: The main outcomes were gastrointestinal, urinary and sexual function and intra and post-operative complications.

Results: Dyschezia, dyspareunia and chronic pelvic pain were significantly reduced following hysterectomy. Furthermore, an improvement of gastrointestinal function was observed, while sexual functions, examined by FSFI and urinary symptoms, examined by BFLUTS, was not shown to be significant.

Conclusion: The modified nerve-sparing radical hysterectomy for DE results in an improvement of symptoms. Nevertheless, despite the nerve-sparing approach, this procedure may be associated with a not-negligible risk of post-operative bladder voiding deficit.

What is new? This is the first study that focuses on parametrial endometriosis using validated questionnaires to assess functional outcomes following radical hysterectomy for DE.