Journal of the European Society for Gynaecological Endoscopy


Factors influencing pregnancy outcome with special attention to modified slow-release insemination and a patient-centred approach in a donor insemination programme: a prospective cohort study

W. Ombelet 1,2, I. Van der Auwera 1, H. Bijnens 1, C. Kremer 3, L. Bruckers 3, G. Mestdagh 1, N. Dhont 1, R. Campo 1

1 Genk Institute for Fertility Technology, Department of Obstetrics and Gynaecology, Schiepse Bos 6, 3600 Genk, Belgium
2 Faculty of Medicine and Life Sciences, Hasselt University, Martelarenlaan 42, Hasselt, Belgium
3 Interuniversity Institute for Biostatistics and statistical Bioinformatics, Data Science Institute, Hasselt University, Martelarenlaan 42, Hasselt, Belgium


clinical pregnancy rate, donor sperm, infertility, intrauterine insemination, patient-centred care, slow-release insemination

Published online: Jul 01 2022


Introduction: A higher pregnancy rate after slow-release insemination instead of bolus injection was described in previous studies. Besides an effective medical treatment most patients wish to receive a patient-centred approach with sufficient emotional support.

Study question: Does a patient-friendly approach with slow-release insemination (SRI) increase the clinical pregnancy rate (CPR) after intrauterine insemination (IUI) with donor semen?

Study design, size, duration: The data of an ongoing prospective cohort study were analysed investigating the results of 1995 donor inseminations in 606 women from July 2011 until December 2018. As from January 2016 the insemination procedure was performed by midwives instead of medical doctors. Instead of bolus injection of sperm a slow-release IUI was done together with a more patient-centred approach.

Materials and Methods: The data of 1995 donor inseminations were analysed to study the importance of different covariates influencing IUI success. Generalized estimating equations (GEEs) were used for statistical analysis. Results of two periods (2011-2015 and 2016-2018) were examined and compared.

Results: Clinical pregnancy rates (with foetal heartbeat) following donor inseminations increased from 16.6 % to 20.8 % per cycle, a non-significant increase (p=0.061).

Conclusion: A more patient-friendly approach with slow-release of processed semen resulted in a non-significant higher clinical pregnancy rate of 4.2 % per cycle after donor insemination.