Journal of the European Society for Gynaecological Endoscopy


Fertility sparing management of uterine adenosarcoma: Case report and literature review

B. Zizolfi 1, V. Foreste 1, A. Di Spiezio Sardo 2, A. Manzi 1, G. Bifulco 1, J. Carugno 3

1 Department of Neuroscience Reproductive Sciences and Dentistry School of Medicine, University of Naples Federico II Naples, Italy;
2 Department of Public Health University of Naples Federico II Naples, Italy;
3 Obstetrics, Gynecology and Reproductive Sciences Department. Minimally Invasive Gynecology Division. University of Miami. Miller School of Medicine. Miami, FL USA.


Hysteroscopy, Adenosarcoma, Uterus, Fertility preservation

Published online: Jan 08 2021


Adenosarcoma is an extremely rare malignancy of the female genital tract composed of stromal sarcoma with a benign epithelial component. Current treatment recommendations include total hysterectomy with bilateral salpingo-oophorectomy, precluding future fertility. Although most frequently diagnosed in postmenopausal women, it is occasionally present in younger women of reproductive age with desire for future fertility. In 2015, we reported the case of a 23-year-old patient diagnosed with uterine adenosarcoma, who having strong desire of future fertility, opted for fertility sparing surgery. At a follow-up five years later, we can now report her case of spontaneous pregnancy and livebirth. A review of the literature concerning fertility outcomes in patients with uterine adenosarcoma undergoing fertility sparing therapeutic options is presented.